L-Arginine, Nitric Oxide, & Fertility
L-Arginine is an amino acid present in human proteins. L-Arginine’s
primary function involves the metabolism of protein
and nitrogen. Moreover, recent Nobel-Prize winning
research has confirmed arginine’s role as a
support mechanism for circulatory and cardiovascular
health. L-Arginine is a key precursor to nitric oxide
(NO), a small molecule that is responsible for relaxing
blood vessels and promoting circulation.
L-Arginine plays several physiological roles, assisting
in healing, helping divest ammonia from the body,
supporting immune function, and promoting endometrial
and cervical secretion. L-Arginine is required by
the body to synthesize nitric oxide (NO), and plays
key roles in the cardiovascular, immune, and reproductive
systems. Nitric oxide supports blood vessel dilation,
which may help circulation and vascular relaxation.
Nitric oxide is formed from arginine via the enzyme
nitric oxide synthase or synthasetase (NOS). One of
its functions is to regulate smooth muscle contraction.
How L-Arginine & NO Work to Promote Fertility
L-Arginine, Nitric Oxide and FertileCM: Toward Enhancing Female
FertileCM is a dietary supplement designed to promote the presence
of cervical mucus by supporting the production of nitric
oxide (NO). Nitric oxide is produced naturally by the
body and is important for numerous bodily functions.
Among these, nitric oxide dilates blood vessels and helps promote blood flow
to the uterus, ovaries, and genitals.
The effect of this process includes an increase of endocervical
secretions during the ovulatory phase in women. In one
key study, "nitric oxide (NO) administration markedly
increased cervical secretion" for women taking
supplementation in the test group, "while no changes
in cervical secretion were seen in the control group."
one key study, "nitric oxide (NO) administration
markedly increased cervical secretion" for women
taking supplementation in the test group, "while
no changes in cervical secretion were seen in the control
addition, other resarech studies indicate that FertileCM,
by providing a key precursor for nitric oxide (NO),
may increase vascular dilatation, blood flow, and muscular
relaxation around the vagina, thereby enhancing libido
and improving sensation to sexual stimulation.
Research demonstrates that the amino acid L-arginine
(contained in the FertileCM formula) may safely increase
cervical mucus, support endometrial secretions and a
healthy uterus during implantation time, and enhance
female sexual arousal.
Nobel Prize Awarded for Nitric Oxide
Prize Awarded to Scientists for Nitric Oxide Discoveries
oxide was named "Molecule of the Year" in
1992 by the journal Science, but it took another 6 years
for those responsible for the major discoveries surrounding
it to win the Nobel Prize.
The discovery of nitric oxide's signaling
role in the cardiovascular and nervous systems is now
nearly 20 years old, but its clinical use is only beginning.
Dr Furchgott, a distinguished professor of pharmacology
at the State University of New York (SUNY) at Brooklyn,
began the studies that led to the identification of
nitric oxide as a biological agent in 1980. He concluded
that endothelial cells produce an unknown signal molecule
that makes vascular smooth muscle cells relax.
In unrelated experiments, Dr Murad,
now chairman of the integrative biology department at
the University of Texas Medical School at Houston, was
analyzing how nitroglycerin works. In 1977, while at
the University of Virginia, he found that nitrates release
nitric oxide, which relaxes smooth muscle cells, resulting
in vasodilation. He was fascinated that the colorless,
odorless gas could act as a signaling molecule.
Dr Ignarro, now a professor of pharmacology
at UCLA School of Medicine in Los Angeles, California,
through a series of analyses concluded in 1986 that
EDRF was identical to nitric oxide. His work, done independently
and together with that of Dr Furchgott, prompted an
increase in research activities in many areas of the
What the Nobel prize recognized was
the scientists' dogged efforts to prove that nitric
oxide, an endogenous gas and also a free radical, could
have this kind of crucial biological effect. Research
has proven the crucial role the gas plays in such fundamental
biological processes as regulation of blood pressure,
functioning and malfunctioning of the immune system,
and activation of mechanisms in the central nervous
Current studies and clinical applications
based on Nobel prize winning research include aspects
of female fertility, including nitric oxide's impact
on increasing cervical mucus secretions during a woman's
fertile time, as well as promoting enodmetrial secretions
to assist in supporting the development of a healthy
endometrial lining. L-arginine, a nitric oxide precursor,
has also been demonstrated to support female sexual
function and arousal.