Studies Supporting the FertileCM Formula
Based on Nobel-Prize winning research, FertileCM is the dietary supplement designed to promote the healthy production of fertile-quality cervical mucus(CM), help build of a healthy endometrium, and increase female sexual function.
In the established studies below, key ingredients in FertileCM have been shown to:
• Naturally and safely support the production of cervical fluids.
• Increase arousal and sexual stimulation.
hydration of the mucin (liquidity of mucus).
• Promote mucus alkalinity and mucosal thinning.
• Support a healthy endometrial lining for successful
implantation of the embryo.
Key studies supporting the FertileCM formula include:
B, Hammarstrom M., 2005. Nitric oxide increases
cervical secretion at the ovulatory phase in the female.
Acta Obstet Gynecol Scand. Sep; 84 (9): 883-6
Abstract: Uterine cervical mucus is crucial for reproduction,
facilitating sperm transport and survival in certain
mammals. Cholinergic autonomic nervous secretory
innervation has been established, and modulation
of secretion by prostaglandins and non-steroidal
anti-inflammatory drugs has been postulated. It
has been suggested that glandular nitric oxide (NO)
production is a prerequisite for the autonomic cholinergic
nervous modulation of cervical, endometrial, and
the seminal vesicle secretion. Most secretory genital
tract cells, female as well as male, seem to display
NO synthase activity. METHODS: Cervical secretion
at ovulation time was studied in 10 women with regular
menstruation. In an in vivo model with repeated
collection of mucus samples during four 60-min periods,
the amount of mucus was estimated in a control experimental
series and in an experimental series following sublingual
administration of the NO donor nitroglycerin. RESULTS:
This administration markedly increased cervical
secretion, while no changes in cervical
secretion were seen in the control experimental
series. CONCLUSIONS: The results suggest that NO production increases cervical secretion.
Thus, cervical secretion may, apart from hormonal
regulation, be influenced by the autonomic nervous
system, and in addition, NO may be a prerequisite
for this influence. This in turn may have implications
on fertilization and fertility regulation.
GI., 2000. NO increases permeability of cultured
human cervical epithelia by cGMP-mediated increase
in G-actin. Am J Physiol Cell Physiol., May;
cervical epithelial cells express mRNA for the nitric
oxide (NO) synthase (NOS) isoforms ecNOS, bNOS,
and iNOS and release NO into the extracellular medium.
N(G)-nitro-L-arginine methyl ester
(L-NAME), an NOS inhibitor, and Hb, an NO scavenger,
decreased paracellular permeability; in contrast,
the NO donors sodium nitroprusside (SNP) and N-(ethoxycarbonyl)-3-(4-morpholinyl)sydnonimine
increased paracellular permeability across cultured
human cervical epithelia on filters, suggesting
that NO increases cervical paracellular
permeability. The objective of the study
was to understand the mechanisms of NO action
on cervical paracellular permeability....
On the basis of these results, it is suggested that
NO acts on guanylate cyclase and stimulates an increase
in cGMP; cGMP, acting via cGMP-dependent protein
kinase, shifts actin steady-state toward G-actin;
this fragments the cytoskeleton and renders cells
more sensitive to decreases in cell size and resistance
of the lateral intercellular space and, hence, to
increases in permeability. These results
may be important for understanding NO regulation
of transcervical paracellular permeability and secretion
of cervical mucus in the woman.
B, Andersson E, Bystrom B, Hammarstrom M. Nitric
oxide induces endometrial secretion at implantation
time. Acta Obstet Gynecol Scand. Nov; 84(11):
Uterine cervical secretory cells receive a sympathetic
cholinergic secretomotor innervation. Glandular nitric
oxide (NO) production has been proposed to be a prerequisite
for muscarine-induced carbohydrate secretion from
endometrial glands and cervical glands at ovulation
time and from the seminal vesicle glands.
Nitric oxide has also been suggested to have a significant
role in the process of implantation and early pregnancy, a process, which has also been
compared with an inflammatory response.... CONCLUSIONS.
The results of this study suggest that glandular
NO production is a prerequisite for the autonomic
nervous modulation of endometrial secretion in the guinea pig and that NO may play a role
in the implantation time.
Other Clinical Data and Background Research for FertileCM
Nobel Prize in Physiology or Medicine 1998: The Nobel
Assembly at the Karolinska Institute in Stockholm,
Sweden, awarded the Nobel Prize in Physiology or Medicine
for 1998 to Robert F Furchgott, Louis J Ignarro and
Ferid Murad for their discoveries concerning "the
nitric oxide as a signalling molecule in the cardiovascular
system". Aitken RJ., 2006. Sperm function tests
and fertility. International Journal of Andrology
A. et al. 1998. Long-term L-arginine supplementation
improves small-vessel coronary endothelial function
in humans. Circulation. 97:2123-2128. Creager M. et
al. 1992. L-arginine improves endothelium-dependent
vasodilation in hypercholesterolemic humans. J Clin
Invest. 90:1248-1253. Moncada S., Higgs A. 1993. The
LArginine –Nitric Oxide Pathway. The New England
Journal of Medicine. 329 (27):2002-2012.
JL, Dunson DB, Stanford JB, Ecochard R, Gnoth C, Colombo
B., 2004. Mucus observations in the fertile window:
a better predictor of conception than timing of intercourse.
Hum Reprod. Apr; 19(4):889-92.
IT and Campbell, S., 1998. Nitric oxide in the endometrium
Human Reproduction Update / European Society of Human
Reproduction and Embryology, Vol.4, No.5 pp.565-569
F, Silva D, Vigil P. 2005. Ultrastructure of the human
periovulatory cervical mucus. J Electron Microsc (Tokyo)
Oct; 54 (5): 479-84.
II, Telesheva LF, Savochkina AIu, Markina OV. 2004.
Anti-inflammatory cytokines of cervical secretions
and the blood serum in women with genital infections.
Zh Mikrobiol Epidemiol Immunobiol Jul-Aug;(4):43-6.
DB, Bigelow JL, Colombo B., 2005. Reduced fertilization
rates in older men when cervical mucus is suboptimal.
Obstet Gynecol Apr;105(4):788-93
D., 1981. A review of cervical mucus and sperm interactions
in humans., Int J Fertil. ;26(3):161-9.
E, et al. 1996. The effect of antioxidant treatment
on human spermatazoa and fertilization rate in an
in vitro fertilization program. Fertil & Steril
WL, te Velde ER., 2005. The influence of sexual function
on the chance of pregnancy. Ned Tijdschr Geneeskd.
GI., 2000. NO increases permeability of cultured human
cervical epithelia by cGMP-mediated increase in G-actin.
Am J Physiol Cell Physiol., May; 278(5):C942-52
J, Bikova S, Ulcova-Gallova Z, Reischig J, Rokyta
Z., 2006. Ovulatory mucus and its pH, arborization
and spermagglutination antibodies in women with fertility
disorders.,Ceska Gynekol Jan;71(1):36-40.
S, Yeung CH, Sonntag B, Nieschlag E, Cooper TG., 2006
Relationship of cytoplasmic droplets to motility,
migration in mucus and volume regulation of human
spermatozoa. Journal of Andrology Feb 10 2006
P, Gnoth C, Baur S, Strowitzki T, Freundl G., 2005.
Determination of the fertile window: reproductive
competence of women--European cycle databases. Gynecol
Endocrinol Jun; 20(6):305-12.
A, Robak-Cholubek D, Sowa I, Jakiel G., 2004. Comparison
of the levels of copper, zinc and iron in cervical
mucus and in blood serum of women of childbearing
age. Ann Univ Mariae Curie Sklodowska 59(1):72-5.
M, Radojcic L, Prokic V, Vojvodic D., 2004. Presence
of interleukin-8 and the IL-1 receptor antagonist
in the cervical mucus of fertile and infertile women.
Vojnosanit Pregl Jul-Aug;61(4):359-64.
JS, Strickland CD, Clements TL. 2004. Guaifenesin
as a treatment for primary dysmenorrhea. J Am Board
Fam Pract. Jul-Aug;17(4):240-6.
H.; Longo, M.; Saade, G.R.; Garfield, R.E. 2003 Nitric
Oxide and its Role During Pregnancy: From Ovulation
to Delivery Current Pharmaceutical Design, Volume
9, Number 5, February 2003, pp. 359-380(22)
B, Hammarstrom M., 2005. Nitric oxide increases endocervical
secretion at the ovulatory phase in the female. Acta
Obstet Gynecol Scand. Sep; 84 (9):883-6.
B, Andersson E, Bystrom B, Hammarstrom M. Nitric oxide
induces endometrial secretion at implantation time.
Acta Obstet Gynecol Scand. Nov; 84(11): 1029-34
Hoessli DC, Rungger-Brandle E, Hussain SA, Walker-Nasir
E. 2003. Role of sialic acid and sulfate groups in
cervical mucus physiological functions. Biochim Biophys
Acta Oct 13;1623(2-3):53-61
M, Ishiyama A, Tabata M, Sasaki Y, Yoneda S, Shiozaki
A, Saito S. 2004. Relationship between cervical mucus
interleukin-8 concentrations and vaginal bacteria
in pregnancy. Am J Reprod Immunol Aug; 52(2):106-12.
B, Dunson DB, Colombo B., 2006. Cervical mucus secretions
on the day of intercourse: An accurate marker of highly
fertile days. European Journal Obstet Gynecol Reproductive
Biololgy Mar 1;125(1):72-8
JB, Smith KR, Dunson DB. 2003. Vulvar mucus observations
and the probability of pregnancy. Obstet Gynecol.
LF, Dolgushin II, Korobeinikova EN. 2004. Neutrophils
and antioxidant activity of cervical secretion in
women with the acute inflammation in the upper section
of the reproductive tract. Zh Mikrobiol Epidemiol